MYB- Maintain Your Brain (led by the Centre for Healthy Brain Ageing, CHeBA) is a randomised controlled trial of multiple online interventions designed to target modifiable risk factors for Alzheimer’s disease and dementia. Risk factors to be addressed are physical inactivity, cognitive inactivity, depression/anxiety, overweight and obesity, and poor dietary habits. Up to four intervention modules (physical activity, nutrition, brain training, and peace of mind) will be administered based on individual risk profiles. All activities and assessments will be conducted on a computer with internet access via the Maintain Your Brain eHealth system. 

Maintain Your Brain will invite over 8,000 individuals through the 45 and Up Study to participate in the trial. These participants will be aged 55-77 years and will not be diagnosed with dementia, Parkinson’s disease or multiple sclerosis. Maintain Your Brain will run for 3 years with annual assessments measuring risk factors and cognition. 

Maintain Your Brain will randomly allocate (like flipping a coin) participants to either a “coaching” or an “information” group. Module activities will differ depending on group allocation, however, all participants will receive up to 4 modules based on their individual risk factors. Each module will run one at a time for 10 weeks with booster sessions (specific to each module) and ongoing monitoring to continue until the end of the trial.